Potential To Address COVID-19 Related Muscle Loss with Fortetropin®

Fortetropin®: Potential To Address COVID-19 Related Muscle Loss

COVID-19 Related Muscle Loss:

In an article published in Science Magazine last week titled “For survivors of severe COVID-19, beating the virus is just the beginning”, Dr. Dale Needham, Professor of Medicine and Medical Director, Critical Care Physical Medicine & Rehabilitation Program, Johns Hopkins University discussed COVID-19 related muscle atrophy [1].

Those who survive a long period on a ventilator are prone to muscle atrophy and weakness. Keeping a critically ill patient moving—raising their arms and legs, and eventually helping them sit up, stand, and walk—can reduce that weakness and get them off the ventilator faster. But because SARS-CoV-2 is so infectious, bringing rehab specialists into patients’ rooms can be a challenge,”

Dr. Needham

Because COVID-19 is such a new disease, there are no peer reviewed clinical studies on COVID-19 related muscle loss at the current time.  However, it is well known that inflammation plays a major role in muscle loss [2-4] and there is a massive inflammatory response associated with COVID-19, often referred to as a “cytokine storm” [5].

The Impact of Muscle Loss:

Elevated Mortality Risk:

  • In a prospective cohort human clinical trial involving 8,762 men (20-80 years old) conducted at the Karolinska Institute, Stockholm, Sweden, muscular strength was found to be inversely proportional to death from all causes [6].
  • In an observational study involving 3,241 women diagnosed with non-metastatic breast cancer, researchers at Harvard Medical School/Brigham & Women’s Hospital found that women with age-related muscle loss known as sarcopenia had a significantly elevated risk of mortality relative to women that were not sarcopenic [7].

Reduced ICU Survival:

COVID-19 has placed a massive strain on ICU bed capacity and the demand for ventilators throughout the world.

  • Researchers at Likou Chang Gung Memorial Hospital, Taiwan reported that among critically ill patients in the ICU, sarcopenia was associated with increased mortality risk.  Sarcopenia was also a predictor of patients becoming ‘difficult to wean’ when placed on ventilators [8].

Elevated Disability Risk:

  • Researchers at the University of Michigan found that subjects (n=8,275 study sample) with muscle weakness as measured by grip strength are at 54% greater risk of suffering an activities of daily living (ADL) disability relative to subjects without muscle weakness [9].
  • In a meta-analysis conducted by researchers at the University of Melbourne, it was concluded that muscle loss is associated with increased risk of falls in the elderly [10].  For elderly people, falls can be devastating if they result in a bone fracture.

Fortetropin®: Advanced Nutrition to Address Muscle Loss

Fortetropin® is an advanced nutrition product made from fertilized chicken egg yolk using a patented, low temperature manufacturing process [11,12] that helps to better retain the natural bioactivity of the proteins, peptides and lipids that are found to be present within fertilized, chicken egg yolk.

  • In a randomized, double blind, placebo-controlled human clinical trial conducted at the University of California, Berkeley, Fortetropin® has been shown to increase the rate of muscle protein synthesis in men and women between 60-75 years of age [13].  
    • According to a preprint published by Researchers at the University of Bern, older adults are most impacted by COVID-19 in terms of hospitalizations and mortality based on data analyzed from Hubei Province and Northern Italy [14].
  • In a randomized, double blind, placebo-controlled study involving 45 men between 18-21 years of age conducted at the University of Tampa, daily consumption of Fortetropin® has been shown to lead to gains in muscle size and strength [15].
  • In a preclinical study involving 100 dogs recovering from TPLO surgery conducted at Kansas State University, daily consumption of Fortetropin® led to reduced muscle atrophy and improved recovery in dogs [16].  Based on these results, a randomized, double blind, placebo-controlled human clinical trial has been initiated at McMaster University to examine the impact of Fortetropin® on disuse atrophy in young men using the unilateral leg immobilization model [17].

Learn more about how Fortetropin® can help improve your muscle health at www.yolked.com.

References

  1. Meng, Si-Jin, and Long-Jiang Yu. “Oxidative stress, molecular inflammation and sarcopenia.” International journal of molecular sciences 11.4 (2010): 1509-1526.
  2. Jensen, Gordon L. “Inflammation: roles in aging and sarcopenia.” Journal of parenteral and enteral nutrition 32.6 (2008): 656-659.
  3. Deans, Christopher, and Stephen J. Wigmore. “Systemic inflammation, cachexia and prognosis in patients with cancer.” Current Opinion in Clinical Nutrition & Metabolic Care 8.3 (2005): 265-269.
  4. Mehta, Puja, et al. “COVID-19: consider cytokine storm syndromes and immunosuppression.” The Lancet (2020).
  5. Ruiz, Jonatan R., et al. “Association between muscular strength and mortality in men: prospective cohort study.” Bmj 337 (2008): a439.
  6. Caan, Bette J., et al. “Association of muscle and adiposity measured by computed tomography with survival in patients with nonmetastatic breast cancer.” JAMA oncology 4.6 (2018): 798-804.
  7. Kou HW, Yeh CH, Tsai HI, Hsu CC, Hsieh YC, Chen WT, Cheng HT, Yu MC, Lee CW. Sarcopenia is an effective predictor of difficult-to-wean and mortality among critically ill surgical patients. PloS one. 2019;14(8).
  8. Duchowny, Kate A., P. J. Clarke, and Mark D. Peterson. “Muscle weakness and physical disability in older Americans: longitudinal findings from the US Health and Retirement Study.” The journal of nutrition, health & aging 22.4 (2018): 501-507.
  9. Yeung, Suey SY, et al. “Sarcopenia and its association with falls and fractures in older adults: A systematic review and meta‐analysis.” Journal of cachexia, sarcopenia and muscle 10.3 (2019): 485-500.
  10. Buxmann, Waldermar, et al. “Process for producing a composition for increasing muscle mass.”  U.S. Patent # 10,165,785, Issue Date: January 1, 2019.
  11. Buxmann, Waldermar, et al. “Process for producing a composition containing active follistatin.”  U.S. Patent #8,815,320, Issue Date: August 26, 2014.
  12. Evans, William J., et al. “Effects of Fortetropin® on the rate of muscle protein synthesis in older men and women: a randomized, double blinded, placebo-controlled study.”  J. Gerontol Med Sci, submitted.
  13. Riou, Julien, et al. “COVID-19 EPIDEMIC IN HUBEI, CHINA, JANUARY AND FEBRUARY 2020.” (2020). https://www.medrxiv.org/content/10.1101/2020.03.04.20031104v2
  14. Sharp, Matthew H., et al. “The effects of fortetropin supplementation on body composition, strength, and power in humans and mechanism of action in a rodent model.” Journal of the American College of Nutrition 35.8 (2016): 679-691.
  15. White, Dana A., et al. “Fortetropin inhibits disuse muscle atrophy in dogs after tibial plateau leveling osteotomy.” PloS one 15.4 (2020): e0231306.
  16. Rakobowchuk, Mark, et al. “Short-term unilateral leg immobilization alters peripheral but not central arterial structure and function in healthy young humans.” European journal of applied physiology 111.2 (2011): 203-210.
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Aaron Gordon
Aaron Gordon
@double0ag
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“This is a special product that can help any athlete reach new heights. I am impressed by the depth of clinical research behind the product and it’s potential to unlock new levels of performance for athletes of all levels.”
David Weck
David Weck
Creator WeckMethod and Founder/CEO of BOSU Fitness.
YOLKED just makes me feel better...not just stronger muscles, but also better skin, nails, hair and overall, I feel more robust! It's a SUPER super food for me. They start with pristine fertilized egg yolks and isolate something called Fortetropin® that has clinically proven benefits for muscle growth, but like I said, I notice it systemically throughout my entire body!
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